Cocaine use disorder (CUD) is a devastating disorder, impacting both individuals and society. Individuals with CUD face many barriers in accessing treatment for CUD, and most individuals with CUD never receive treatment. In this review, we provide an overview of CUD, including risk factors for CUD, common co-occurring disorders, acute and chronic effects of cocaine use, and currently available pharmacological and behavioral treatments. Future studies with larger sample sizes and testing treatment combinations are warranted. However, individuals with CUD and co-occurring disorders (eg, a mood or anxiety disorder) may benefit from medication treatments. Following the discussion of current treatments, we highlight some promising emerging treatments, as well as offer a framework that can be used in building a treatment plan for individuals with CUD.
The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare providers. Pharmacological and behavioral treatments are the most effective options for cocaine addiction. Outpatient treatment, inpatient treatment, medications, therapy, or a combination of different treatment programs can help you recover from addiction.
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For this reason, you might hear the terms “crack” and “freebase” used interchangeably. To find a support group in your area, talk to a healthcare provider or go online. All stimulants act to enhance the extracellular concentrations of dopamine, norepinephrine, and serotonin. Some people report that cocaine helps them think and perform tasks more quickly. Cocaine is a drug made from the leaves of the coca plant native to South America.
There are also effective medications approved by the Food and Drug Administration to treat opioid, tobacco, and alcohol use disorders. The course and length of treatment vary based on the specific needs of the individual. The presence cocaine addiction treatment of cocaine withdrawal symptoms may make it difficult for cocaine users to attain a period of initial abstinence. Cocaine withdrawal symptoms include dysphoric mood, fatigue, sleep disturbance, appetite changes, and irritability.
Three trials of long-acting amphetamine have been conducted thus far, with promising results. The first two trials (28, 29) were conducted by Grabowski et al. at the University of Texas. The earliest, 12-week clinical trial (28) involved 128 patients with DSM-IV cocaine dependence who were randomly assigned to placebo, low-dose dextroamphetamine (30 mg daily), or high-dose dextroamphetamine (60 mg daily).